Yamamoto, K., Tsutsumi, S., Ikeda, Y.: Establishment of cocrystal cocktail grinding method for rational screening of pharmaceutical cocrystals.

25, 12вЂ“15 (2015)ДЄakeroy, C.B., Salmon, D.J., Smith, M.M., Desper, J.: Cyanophenyloximes: reliable and versatile tools for hydrogen-bond directed supramolecular synthesis of cocrystals. Imchalee, R., Charoenchaitrakool, M.: Gas anti-solvent processing of a new sulfamethoxazole-L-malic acid cocrystal. Wang, L., Wen, X., Li, P., Wang, J., Yang, P., Zhang, H., Deng, Z.: 2:1 5-fluorocytosineвЂ“acesulfame CAB cocrystal and 1:1 5-fluorocytosineвЂ“acesulfame salt hydrate with enhanced stability against hydration. 187, 171вЂ“176 (2013)Дuggirala, N.K., Smith, A.J., Wojtas, L., Shytle, R.D., Zaworotko, M.J.: Physical stability enhancement and pharmacokinetics of a lithium ionic cocrystal with glucose. Shayanfar, A., Asadpour-Zeynali, K., Jouyban, A.: Solubility and dissolution rate of a carbamazepineвЂ“cinnamic acid cocrystal. These findings are all beneficial to the development of the cocrystallization process of the CBZвЂ“NCT cocrystal.Д¬hilds, S.L., Stahly, G.P., Park, A.: The saltвЂ“cocrystal continuum: the influence of crystal structure on ionization state. For avoiding single component crystallization, the supersaturation ratio of cocrystal to drug should be increased to inhibit carbamazepine nucleation. Additionally, in the cocrystal formation process, the nucleation of cocrystal and carbamazepine in a slurry crystallization, is a competitive relationship.

Employing solvent mixtures could make the phase diagrams of the CBZвЂ“NCT cocrystal more symmetric and enlarge the safe operation region for the cocrystal.

In terms of this issue, it was found that the solvent mixture can have a significant effect on the symmetry of phase diagrams. The phase diagram of a CBZвЂ“NCT cocrystal in pure ethanol at 298.15В K is asymmetric, which leads to an excess of coformer being needed to isolate the cocrystal. The solubility of the 1:1 cocrystal is correlated as a function of the cocrystal former (nicotinamide) concentration by a mathematical model based on solubility product theory and the complexation process. The phase diagrams for carbamazepine (CBZ) and nicotinamide (NCT) in ethanol and ethanol/ethyl acetate mixture were constructed at 298.15В K and 313.15В K under atmospheric pressure using the static method.

Max and min solvent ternary diagram